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KMID : 0352720060300030128
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Journal of Ginseng Research
2006 Volume.30 No. 3 p.128 ~ p.131
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A Growth Inhibition Effect of Saponin from Red Ginseng on Some Pathogenic Microorganisms
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Kwak Yi-Seong
Hwang Mi-Sun
Kim Seok-Chang
Kim Chun-Suk
Do Jae-Ho
Park Chae-Kyu
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Abstract
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Saponin isolated from red ginseng was added to cultures of Staphylococcus aureus and Candida albicans in order to investigate saponin’’s influence on the growth of some pathogenic bacteria and yeasts. S. aureus and C. albicans were incubated at $38^{\circ}C\;and\;28^{\circ}C$ for 5 days with 100 rpm after addition of 0.013, 0.125, 0.500 and 1.000% (w/v, final concentration) of saponin, respectively. After incubated for 1 day, 2 days or 5 days, pH and viable cell counts of the cultures were investigated. The both of pH of S. aureus and C. albicans were decreased in concentration-dependent manner. Viable cell counts after incubation of 5 days were $1.0\;{\times}\;10^8,\;9.4\;{\times}\;10^7,\;1.0\;{\times}\;10^3$ and 0 CFU/ml, respectively, when compared with $1.8{\times}10^8\;CFU/ml$ of saponin non-treated group. Especially, 1.0% concentration of saponin inhibited completely the growth of S. aureus. While, viable cell count in C. albicans somewhat lower values than that of saponin non-treated group, but the values not significant. These results suggest that ginseng saponin inhibit the growth of S. aureus in a concentration-dependent manner, but not the growth of C. albicans.
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KEYWORD
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Red ginseng, saponin, growth inhibition, Staphylococcus aureus, Candida albicans
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